Influence of low and high pressure baroreceptors on plasma renin activity in humans

The effects of low and high pressure baroreceptors on plasma renin activity (immunoassay) were evaluated using graded lower body suction (LBS) in six healthy men. LBS at -10 and -20 mmHg for 10 min decreased central venous pressure without changing arterial pressure and thereby presumably reduced low but not high pressure baroreceptor inhibition of renin release. LBS at these levels produced forearm vasoconstriction, but did not increase renin. LBS at -40 mmHG decreased central venous and arterial pulse pressure and thus reduced both low and high pressure baroreceptor inhibition. LBS at this level produced forearm vasoconstriction and tachycardia and increased renin. In summary, reduction in low pressure baroreceptor inhibition in humans did not increase renin in the presence of physiological tonic inhibition from high pressure baroreceptors. Increases in renin did not occur until there was combined reduction of high and low pressure baroreceptor inhibition on plasma renin activity

Influence of central venous pressure upon sinus node responses to arterial baroreflex stimulation in man

Measurements were made of sinus node responses to arterial baroreceptor stimulation with phenylephrine injection or neck suction, before and during changes of central venous pressure provoked by lower body negative pressure or leg and lower truck elevation. Variations of central venous pressure between 1.1 and 9.0 mm Hg did not influence arterial baroreflex mediated bradycardia. Baroreflex sinus node responses were augmented by intravenous propranolol, but the level of responses after propranolol was comparable during the control state, lower body negative pressure, and leg and trunk elevation. Sinus node responses to very brief baroreceptor stimuli applied during the transitions of central venous pressure also were comparable in the three states. The authors conclude that physiological variations of central venous pressure do not influence sinus node responses to arterial baroreceptor stimulation in man

Conditional Lower Bounds for Space/Time Tradeoffs

In recent years much effort has been concentrated towards achieving polynomial time lower bounds on algorithms for solving various well-known problems. A useful technique for showing such lower bounds is to prove them conditionally based on well-studied hardness assumptions such as 3SUM, APSP, SETH, etc. This line of research helps to obtain a better understanding of the complexity inside P. A related question asks to prove conditional space lower bounds on data structures that are constructed to solve certain algorithmic tasks after an initial preprocessing stage. This question received little attention in previous research even though it has potential strong impact. In this paper we address this question and show that surprisingly many of the well-studied hard problems that are known to have conditional polynomial time lower bounds are also hard when concerning space. This hardness is shown as a tradeoff between the space consumed by the data structure and the time needed to answer queries. The tradeoff may be either smooth or admit one or more singularity points. We reveal interesting connections between different space hardness conjectures and present matching upper bounds. We also apply these hardness conjectures to both static and dynamic problems and prove their conditional space hardness. We believe that this novel framework of polynomial space conjectures can play an important role in expressing polynomial space lower bounds of many important algorithmic problems. Moreover, it seems that it can also help in achieving a better understanding of the hardness of their corresponding problems in terms of time

Fine-Grained Complexity of Analyzing Compressed Data: Quantifying Improvements over Decompress-And-Solve

Can we analyze data without decompressing it? As our data keeps growing, understanding the time complexity of problems on compressed inputs, rather than in convenient uncompressed forms, becomes more and more relevant. Suppose we are given a compression of size $n$ of data that originally has size $N$, and we want to solve a problem with time complexity $T(\cdot)$. The naive strategy of "decompress-and-solve" gives time $T(N)$, whereas "the gold standard" is time $T(n)$: to analyze the compression as efficiently as if the original data was small. We restrict our attention to data in the form of a string (text, files, genomes, etc.) and study the most ubiquitous tasks. While the challenge might seem to depend heavily on the specific compression scheme, most methods of practical relevance (Lempel-Ziv-family, dictionary methods, and others) can be unified under the elegant notion of Grammar Compressions. A vast literature, across many disciplines, established this as an influential notion for Algorithm design. We introduce a framework for proving (conditional) lower bounds in this field, allowing us to assess whether decompress-and-solve can be improved, and by how much. Our main results are: - The $O(nN\sqrt{\log{N/n}})$ bound for LCS and the $O(\min\{N \log N, nM\})$ bound for Pattern Matching with Wildcards are optimal up to $N^{o(1)}$ factors, under the Strong Exponential Time Hypothesis. (Here, $M$ denotes the uncompressed length of the compressed pattern.) - Decompress-and-solve is essentially optimal for Context-Free Grammar Parsing and RNA Folding, under the $k$-Clique conjecture. - We give an algorithm showing that decompress-and-solve is not optimal for Disjointness

Antibiotic Spacers in Shoulder Arthroplasty: Comparison of Stemmed and Stemless Implants.

Background: Antibiotic spacers in shoulder periprosthetic joint infection deliver antibiotics locally and provide temporary stability. The purpose of this study was to evaluate differences between stemmed and stemless spacers. Methods: All spacers placed from 2011 to 2013 were identified. Stemless spacers were made by creating a spherical ball of cement placed in the joint space. Stemmed spacers had some portion in the humeral canal. Operative time, complications, reimplantation, reinfection, and range of motion were analyzed. Results: There were 37 spacers placed: 22 were stemless and 15 were stemmed. The stemless spacer population was older (70.9 ± 7.8 years vs. 62.8 ± 8.4 years, p = 0.006). The groups had a similar percentage of each gender (stemless group, 45% male vs. stemmed group, 40% male; p = 0.742), body mass index (stemless group, 29.1 ± 6.4 kg/m2 vs. stemmed group, 31.5 ± 8.3 kg/m2; p = 0.354) and Charlson Comorbidity Index (stemless group, 4.2 ± 1.2 vs. stemmed group, 4.2 ± 1.7; p = 0.958). Operative time was similar (stemless group, 127.5 ± 37.1 minutes vs. stemmed group, 130.5 ± 39.4 minutes). Two stemless group patients had self-resolving radial nerve palsies. Within the stemless group, 15 of 22 (68.2%) underwent reimplantation with 14 of 15 having forward elevation of 109° ± 23°. Within the stemmed group, 12 of 15 (80.0%, p = 0.427) underwent reimplantation with 8 of 12 having forward elevation of 94° ± 43° (range, 30° to 150°; p = 0.300). Two stemmed group patients had axillary nerve palsies, one of which self-resolved but the other did not. One patient sustained dislocation of reverse shoulder arthroplasty after reimplantation. One stemless group patient required an open reduction and glenosphere exchange of dislocated reverse shoulder arthroplasty at 6 weeks after reimplantation. Conclusions: Stemmed and stemless spacers had similar clinical outcomes. When analyzing all antibiotic spacers, over 70% were converted to revision arthroplasties. The results of this study do not suggest superiority of either stemmed or stemless antibiotic spacers

{SETH}-Based Lower Bounds for Subset Sum and Bicriteria Path

Subset-Sum and k-SAT are two of the most extensively studied problems in computer science, and conjectures about their hardness are among the cornerstones of fine-grained complexity. One of the most intriguing open problems in this area is to base the hardness of one of these problems on the other. Our main result is a tight reduction from k-SAT to Subset-Sum on dense instances, proving that Bellman's 1962 pseudo-polynomial $O^{*}(T)$-time algorithm for Subset-Sum on $n$ numbers and target $T$ cannot be improved to time $T^{1-\varepsilon}\cdot 2^{o(n)}$ for any $\varepsilon>0$, unless the Strong Exponential Time Hypothesis (SETH) fails. This is one of the strongest known connections between any two of the core problems of fine-grained complexity. As a corollary, we prove a "Direct-OR" theorem for Subset-Sum under SETH, offering a new tool for proving conditional lower bounds: It is now possible to assume that deciding whether one out of $N$ given instances of Subset-Sum is a YES instance requires time $(N T)^{1-o(1)}$. As an application of this corollary, we prove a tight SETH-based lower bound for the classical Bicriteria s,t-Path problem, which is extensively studied in Operations Research. We separate its complexity from that of Subset-Sum: On graphs with $m$ edges and edge lengths bounded by $L$, we show that the $O(Lm)$ pseudo-polynomial time algorithm by Joksch from 1966 cannot be improved to $\tilde{O}(L+m)$, in contrast to a recent improvement for Subset Sum (Bringmann, SODA 2017)

A high-wavenumber boundary-element method for an acoustic scattering problem

In this paper we show stability and convergence for a novel Galerkin boundary element method approach to the impedance boundary value problem for the Helmholtz equation in a half-plane with piecewise constant boundary data. This problem models, for example, outdoor sound propagation over inhomogeneous flat terrain. To achieve a good approximation with a relatively low number of degrees of freedom we employ a graded mesh with smaller elements adjacent to discontinuities in impedance, and a special set of basis functions for the Galerkin method so that, on each element, the approximation space consists of polynomials (of degree $\nu$) multiplied by traces of plane waves on the boundary. In the case where the impedance is constant outside an interval $[a,b]$, which only requires the discretization of $[a,b]$, we show theoretically and experimentally that the $L_2$ error in computing the acoustic field on $[a,b]$ is ${\cal O}(\log^{\nu+3/2}|k(b-a)| M^{-(\nu+1)})$, where $M$ is the number of degrees of freedom and $k$ is the wavenumber. This indicates that the proposed method is especially commendable for large intervals or a high wavenumber. In a final section we sketch how the same methodology extends to more general scattering problems

Isolation, molecular identification and under lab evaluation of the entomopathogenic fungi M. anisopliae and B. bassiana against the Red Palm Weevil R. ferrugineus in Gaza Strip

Plant diseases generate challenging problems in commercial, agriculture and pose real economic threats to both conventional and organic farming systems. The red palm weevil (Rhynchophorus ferrugineus) (RPW) is one of the most destructive pests of palms in the world. Nowadays, control methods revolve around treatments based on chemicals, biotechnological systems using semi-chemicals or the development of the sterile insect technique (hardly sustainable at this time) and biological control. Biological control as the use of natural microorganisms, extracted products from microorganisms or genetically improved to resist or eliminate of pathogens. Our aim was to evaluate the entomopathogenicity of indigenous Beauveria bassiana and Metarhizium anisopliae obtained in Gaza strip against larvae and adults of R. ferrugineus in order to identify indigenous strains potentially suitable for Red Palm Weevil biological control. B. bassiana & M. anisopliae were isolated from larvae and adult dead of RPW from different position of Gaza strip. Morphological analysis of the isolated fungi and molecular identification was determined using PCR technique. Also, the efficiency of the isolated fungi were evaluated under lab conditions and optimized as a biological agent. On the anther hand, the ability of treated RPW male to infect females is examined and calculated using Abbott's formula. Our results showed that the B. bassiana and M. anisopliae exhibited a good biological control agent against larvae and adults of RPW. The pathogenicity of the two most virulent isolates and the toxicity assay on larvae showed a highest mortality percentage nearly to 100